Fourth Wall Jokes are moments when characters address the fact that they're in a TV show. "My Gym Partner's a Monkey", has made many jokes, where various characters have mentioned being in a cartoon, and referenced objects that exist outside their fictional universe like the audience, their voice actors, camera tricks, etc.
- At the end of the episode, as the iris faded out, Principal Pixiefrog's butt was so big, it was closed in on by the iris. Pixiefrog then turned to the screen and said "Hey, you've made you're point." before the iris faded out as normal.
- Jake leaned on the fourth wall, implying how something strange always happens at the beginning of every episode, starting a story.
- During the ending credits, a wild lion gave a Public Service Announcement on the way lions were stereotyped in the episode they just showed.
- Windsor tells Adam that he sees him in a different way than he used to for the past two seasons.
- Jake criticized the title of the show being "My Gym Partner's a Monkey", since he and Adam are only occasionally seen in gym together.
- Windsor verbally mentions how his flashback will help with putting exposition on the reason Slips got left behind in school.
- Mrs. Warthog says that pitch forks and torches are classic components of cartoon riots.
- Principal Pixiefrog quotes the phrase "The Citronella Solution" in dialogue and then brags to Mrs. Warthog about how he was able to work the episode's title into the dialogue. Mrs. Warthog then shamefully hands him a dollar bill, implying that he must have placed a bet on that.
- Jake says that Soupy Baskington swallowing a couch will be funnier than the time they showed his butt in the opening credits.
- Jake asks Adam "Remember when this show used to be about a boy who went to an all animal school?"
- Captain Corporate tells Windsor that when he becomes famous, he'll get his own show on Cartoon Network. An imagination sequence then shows a parody on My Gym Partner's a Monkey's Theme Song, with Windsor in the place of Jake, called "My Gym Partner's a Gorilla".
- Adam acknowledges the "cartooniness" of the Scottish Tourists.
- Miss Chameleon tells Adam that with his vocal talent, he could get a job, as a cartoon voice actor. Slips asks what a cartoon is and Windsor explains that he's sitting in one. When Jake fails to be as vocally gifted as Adam, Miss Chameleon tells him he still has a chance with writing cartoons.
- When Adam says he has an idea, Jake says that he usually does at that point in the episode.
- Adam and Jake inaugurate their plan, Jake mentions them doing so through montage.
- Adam predicts that something bad will happen to Jake, given that a conflict occurs in every episode.
- Jake mentions that Adam has a girly voice.
- Principal Pixiefrog touches upon Adam's feminine voice.
- Pixiefrog also states that when Adam signed his contract, he signed away the rights to making a TV show based off of his life story.